In the presence of low oxygen with sufficient glucose, downregulating which protein would likely cause muscle cells to die due to low ATP?

In low oxygen conditions with sufficient glucose, muscle cells rely on anaerobic glycolysis to produce ATP. Glucose transporters (like GLUT1 and GLUT4) are essential for importing glucose into the cells. If the glucose transporter is downregulated, glucose uptake decreases, leading to reduced glycolysis and ATP production. Consequently, muscle cells would die from energy deprivation.