Which condition will significantly reduce the total amount of proteins in a cell?

Ubiquitin ligases are responsible for tagging proteins for degradation by the proteasome, a cellular machinery that breaks down proteins. When a cell expresses high concentrations of ubiquitin ligases, it will target more proteins for degradation, leading to a significant reduction in the total amount of proteins within the cell. This process helps in regulating protein levels and maintaining cellular homeostasis.